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目的 :观察Nd:YAG激光与白芍总苷胶囊联合治疗糜烂型口腔扁平苔藓(oral lichen planus,OLP)的临床疗效。方法:采用随机数字表法将60例OLP患者分为观察组(28例)和对照组(32例)。2组患者均口服白芍总苷胶囊,观察组辅以Nd:YAG激光照射。于治疗前、治疗后3个月对2组患者的临床疗效进行比较,采用SPPS17.0软件包对数据进行统计学分析。结果:治疗3个月后发现观察组VAS及体征评分(分别为1.36±1.39分、2.32±1.56分)及对照组VAS及体征评分(分别为2.75±1.67分、3.66±1.33分)均显著优于治疗前(P<0.05),观察组患者VAS及体征评分均显著优于对照组(P<0.05);观察组治疗有效率为82.1%,显著高于对照组的53.1%(P<0.05)。结论:Nd:YAG激光联合口服白芍总苷胶囊能够显著提高糜烂型OLP的疗效,且安全性良好,值得临床推广应用。
Objective: To observe the clinical efficacy of Nd: YAG laser combined with total glucosides of paeony in the treatment of erosive oral lichen planus (OLP). Methods: Sixty patients with OLP were divided into observation group (n = 28) and control group (n = 32) by random number table method. The patients in both groups were orally given the total glycosides of paeony, the observation group supplemented with Nd: YAG laser irradiation. Before treatment and 3 months after treatment, the clinical efficacy of the two groups of patients were compared, and the data were analyzed by SPPS17.0 software package. Results: After 3 months of treatment, the VAS scores and VAS score (1.36 ± 1.39 and 2.32 ± 1.56 respectively) and VAS and VAS scores (2.75 ± 1.67 and 3.66 ± 1.33 respectively) in the control group were significantly higher Before treatment (P <0.05), VAS and score of patients in observation group were significantly better than those in control group (P <0.05). The effective rate of observation group was 82.1%, which was significantly higher than 53.1% of control group (P <0.05) . Conclusion: Nd: YAG laser combined with oral total paeoniflorin can significantly improve the curative effect of erosive OLP, and it is safe and worthy of clinical application.