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目的探讨魔芋多糖(Konjac polysaccharide,KP)对小鼠胃肠组织的胃动素与生长抑素的影响。方法将实验动物随机分为正常对照(NC)和KP高、中、低剂量(KPH、KPM、KPL)4组,前者给予普通饲料,后三者每100g普通饲料中分别加入KP0.8、0.4和0.2g,连续喂饲20d。应用放射免疫法测定小鼠胃肠组织胃动素生长抑素水平,血糖仪测定血糖并称重体重、体脂和粪便湿重等指标。结果KPH组胃动素为8.26±0.53ng/g,较NC组升高;生长抑素为207.32±21.89ng/g,较NC组降低。各项指标的差别均有显著性意义(P<0.05)。结论KP可提高小鼠胃肠组织的胃动素水平,降低其生长抑素水平。
Objective To investigate the effects of Konjac polysaccharide (KP) on motilin and somatostatin in mice gastrointestinal tissues. Methods The experimental animals were randomly divided into four groups: normal control (NC) and KP high, medium and low doses (KPH, KPM, KPL). The former was given general feed, the latter three were fed with KP 0.8, And 0.2g, continuous feeding 20d. The levels of somatostatin somatostatin in mice gastrointestinal tissue were measured by radioimmunoassay, the blood glucose was measured by the blood glucose meter and the body weight, body fat and wet weight of feces were measured. Results Motilin in KPH group was 8.26 ± 0.53ng / g, which was higher than that in NC group. The somatostatin level was 207.32 ± 21.89ng / g, which was lower than that in NC group. The differences of each index were significant (P <0.05). Conclusion KP can increase the level of motilin in gastrointestinal tissues of mice and decrease the level of somatostatin.