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目的方法原发性高血压６５例，氨氯地平每日晨服５ｍｇ。随机分为Ａ、Ｂ两组，Ａ组为短疗程用药８周共３５例；Ｂ组为长疗程用药２４周共３０例。结果两组血压下降均为治疗后第１～２周最为明显，继续巩固疗效直至疗程结束为止。两组显效率各为６８．５７％、７３．３３％，总有效率各为８２．８６％，９０％。Ａ组治疗后心率（ＨＲ）无明显改变，Ｂ组则有明显减缓（Ｐ＜０．０１）。Ａ组８周后左房（ＬＡ）缩小，Ｅ／Ａ比值增大；Ｂ组２４周后除上述改变外，室间隔厚度（ＩＶＳ）、左室后壁厚度（ＬＶＰＷ）明显消退，总有效率达８６．６７％，７６．６７％，左心室质量指数（ＬＶＭＩ）从治疗前１３８．２６±２８．５６减至１１４．３７±１６．２９。两组中以Ｅ／Ａ比值最为敏感，发生最早。治疗１２周后出现左心室肥厚的消退。副作用为头痛、恶心、轻度踝部水肿、面红及疲劳等。结论
The purpose of the method of 65 cases of essential hypertension, amlodipine daily morning service 5mg. Randomly divided into A, B two groups, A group of short courses of treatment for a total of 35 cases in 8 weeks; B group for a long course of treatment of 24 weeks, a total of 30 cases. Results The decrease of blood pressure in the two groups was the most obvious in the first 1-2 weeks after treatment, and continued to consolidate the effect until the end of treatment. The effective rates of the two groups were 68.57% and 73.33%, respectively. The total effective rates were 82.86% and 90% respectively. The heart rate (HR) of group A did not change significantly after treatment, and group B was significantly slowed down (P <0.01). In group A, the left atrium (LA) decreased and the ratio of E / A increased after 8 weeks. In group B, the ventricular septal thickness (IVS) and left ventricular posterior wall thickness (LVPW) Up to 86.67% and 76.67%, respectively. The LVMI decreased from 138.26 ± 28.56 before treatment to 114.37 ± 16.29. The two groups in the E / A ratio is the most sensitive, occurred the earliest. Left ventricular hypertrophy subsided after 12 weeks of treatment. Side effects of headache, nausea, mild ankle edema, redness and fatigue. in conclusion