原癌基因Fra-1是核转录因子AP-1家族的成员,通过亮氨酸拉链结构域与Jun蛋白形成异源二聚体,调控靶基因的转录。在胚胎发育过程中,通过促进成骨细胞、破骨细胞分化,影响骨基质蛋白的合成,参与骨形成。近年来,发现Fra-1在恶性肿瘤的迁徙、侵袭中发挥着重要的作用,其可能成为肿瘤治疗的新靶点。本文综述了Fra-1在骨形成及肿瘤中的研究进展。 Prot-oncogene Fra-1, a member of the AP-1 family of nuclear transcription factors, regulates transcription of target genes by forming heterodimers with the Jun protein through the leucine zipper domain. In the process of embryonic development, through the promotion of osteoblasts, osteoclasts, affect the synthesis of bone matrix protein, involved in bone formation. In recent years, Fra-1 has been found to play an important role in the migration and invasion of malignant tumors, which may become a new target for the treatment of cancer. This review summarizes the research progress of Fra-1 in bone formation and tumor.