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目的探讨中药补骨脂及鸦胆子对大鼠卡氏肺孢子虫肺炎的防治效果。方法用地塞米松皮下注射建立大鼠卡氏肺孢子虫肺炎动物模型,用补骨脂、鸦胆子及两者合剂治疗实验鼠,观察其肺脑组织病理、肺脑组织和血清中MDA(丙二醛)、XOD(黄嘌呤氧化酶)、GSH(谷胱甘肽)等指标变化。结果补骨脂、鸦胆子及合剂治疗实验大鼠体重明显回升,与模型对照差异有显著性(P<005);各治疗组的包囊减少率均高于60%,合剂治疗组不优于各单独治疗组,鸦胆子及合剂治疗组清除氧自由基能力较强。结论鸦胆子及补骨脂对大鼠卡氏肺孢子虫肺炎具有一定疗效。
Objective To investigate the preventive and therapeutic effects of psoralen and brucea javanica on pneumocystis carinii pneumonia in rats. Methods The animal model of pneumocystis carinii pneumonia was established by subcutaneous injection of dexamethasone. The experimental rats were treated with psoralen, brucea javanica and their mixture. The pathological, lung and brain tissues and serum MDA in the brain were observed. Aldehyde), XOD (xanthine oxidase), GSH (glutathione) and other indicators change. Results The body weight of rats treated with psoralen, brucea javanica and mixture significantly increased, which was significantly different from that of the model (P<005). The cyst reduction rate of each treatment group was higher than 60%, and the combination treatment group was not superior to the treatment group. In each treatment group, Brucea javanica and combination treatment group had a strong ability to scavenge oxygen free radicals. Conclusion Brucea javanica and psoralen have a certain effect on Pneumocystis carinii pneumonia in rats.