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目的:分析递增负荷运动对SD大鼠股骨和腰椎最大载荷的影响.方法:170只3月龄雌性SD大鼠随机分为基础对照组(C_0)和8个训练周期(2W、4W、6W、8W、9W、1lW、13W和15W)的对照组(C_(2w),C_(4w)…C_(15w))与运动组(T_(2w),T_(4w)…T_(15w)),每组各10只.运动组进行递增负荷跑台训练.实验后,取左股骨和第二腰椎,分别采用三点弯试验和压力试验测定其最大载荷.结果:在15周的实验期内,对照组与运动组股骨最大载荷变化趋势比较一致,无显著性差异;对照组与运动组第二腰椎最大载荷则表现出显著性差异(P<0.001).结论:SD大鼠在生长过程中股骨及第二腰椎最大载荷变化存在差异,递增负荷运动对SD大鼠骨最大载荷的作用因运动强度及骨质的差异而不同.“,”Objective The aim of the study is to investigate whether the progressive incremental exercise can induce the change in bone maximum force.Methods One hundred and seventy healthy SD rats,aged 3 months,were used as samples after adaptive exercise for one week,and then they were divided to a basic control group(C_0),8 control groups and 8 exercise groups according to the training duration(2W,4W,6W,8W,9W,11W,13W and 15W).Based on Bedford and our pre-study.the longest training duration of the rats was 15 weeks.The maximum force(F) of femoral bone and the 2nd lumbar vertebrae(L_2)were tested by three-point bending test and compressive test separately.Results It was shown that there was no pronounced difference in F of femoral bone between con trol groups and exercise groups.But significant differences in F of L_2 were found between the control groups and exercise groups(P<0.001).Conclusions Changes in different degree were found in the F of femoral bone and L_2 during the process of growth.The differential effects of incremental exercise on F were caused by the difference in training intensities and in the bone types.