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目的观察Bcl-2在牙周病的发生发展的变化中的敏感程度,观察牙周塞治剂是否能加强盐酸米诺环素软膏治疗牙周病的效果。方法选40只日本大耳白兔,其中4只作为对照组,其余36只日本大耳白兔随机分为牙周炎未治疗组(牙周炎组12只)、牙周炎应用盐酸米诺环素软膏组(派丽奥组12只),牙周炎应用盐酸米诺环素软膏和牙周塞治剂组(塞治剂12只)。检测Bcl-2在牙龈组织中的表达及各组牙周病的指标比较。结果应用盐酸米诺环素软膏合用牙周塞治剂后,牙周袋深度(PD)、龈沟出血指数(SBI)明显降低(P<0.05),Bcl-2在牙龈组织中的表达明显升高(P<0.05)。结论牙周塞治剂能明显提高派丽奥治疗兔牙周炎的效果,Bcl-2是牙周炎的敏感指标。
Objective To observe the sensitivity of Bcl-2 in the development of periodontal disease and to observe whether the periodontal treatment can enhance the effect of minocycline hydrochloride ointment on periodontal disease. Methods Forty Japanese white rabbits were selected, of which 4 were used as control group. The remaining 36 Japanese white rabbits were randomly divided into untreated group (periodontitis group 12), periodontitis group Cyclophilin ointment group (12 cases of Palio group), minocycline hydrochloride ointment group and periodontal plug treatment group (12 cases). The expression of Bcl-2 in gingival tissue and the comparison of the indexes of periodontal disease in each group were detected. Results The PD and SBI were significantly decreased (P <0.05) and the expression of Bcl-2 in gingival tissues was significantly increased after oral administration of minocycline ointment (P <0.05) P <0.05). Conclusions Periodontal treatment can significantly improve the effect of Pilar on periodontitis in rabbits. Bcl-2 is a sensitive indicator of periodontitis.