论文部分内容阅读
目的：探讨C－erbB－2及P~(53)蛋白在乳腺非典型增生及乳腺癌不同组织学类型中的表达水平及诊断价值。方法：对乳腺非典型增生及乳腺病不同类型的手术标本存档蜡块115例进行C－erbB－2及P~(53)蛋白的免疫组化检测。结果：乳腺非典型增生自轻、中、重度至病变过程中C－erbB－2蛋白的异常表达呈递增性升高，癌变阶段达顶峰，其阳性检测率分别为5．56％、40％、44％、50％。P~(53)蛋白在轻度非典型增生组织中无表达，自中、重度非典型增生时出现由性表达，至浸润性癌时过高峰，其阳性检测率分别为6.7％、33．3％、41．67％。结论：c-erbB－2基因蛋白的异常表达对乳腺癌发生发展的早期具有重要的诊断参考价值。而P~(53)蛋白的异常表达则对早、中、晚期乳腺癌的诊断、恶性程度及预后的判断具有重要参考价值。
Objective: To investigate the expression level and diagnostic value of C-erbB-2 and P53 in different histological types of breast atypical hyperplasia and breast cancer. METHODS: Immunohistochemical detection of C-erbB-2 and P53 protein was performed in 115 specimens of atypical hyperplasia and mastopathy. RESULTS: Abnormal expression of C-erbB-2 protein increased gradually from the mild, moderate and severe stages of breast atypical hyperplasia to the peak during the cancerous stage. The positive detection rates were 5.56% and 40%, respectively. 44%, 50%. P53 protein was not expressed in mild atypical hyperplasia tissues, but it was expressed sexually during moderate to severe atypical hyperplasia, and reached the peak at invasive carcinoma. Its positive detection rates were 6.7% and 33.3 respectively. %, 41.67%. Conclusion: Abnormal expression of c-erbB-2 gene protein has important diagnostic value for the early stage of breast cancer development. The abnormal expression of P53 protein has important reference value for the diagnosis, malignancy and prognosis of early, middle and advanced breast cancer.