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目的研究低剂量电离辐射对小鼠免疫系统影响的剂量率效应。方法以~(60)Co-γ射线为辐照源,低、中和高3个辐射剂量(0．075、0．5、2．0Gy),恒定剂量率(0．5 mGy/min)全身一次性照射小鼠,ELISA检测照射4h后血浆IL-12和IL-10的含量。结果低、中剂量照射后,血浆中IL-12、IL-10和IL-12/IL-10出现程度几乎相同地下降；但高剂量照射后,IL-12进一步显著下降,而IL-10上升至对照组水平,IL-12/IL-10比值进一步下降。结论恒定0．5mGy/min剂量率的~(60)Co-γ射线照射可损伤机体免疫功能,在0．075～0．5Gy剂量范围内损伤轻微,在2．0Gy时损伤明显,表明低剂量率电离辐射对免疫系统具有损伤作用。
Objective To study the dose-rate effect of low-dose ionizing radiation on the immune system in mice. Methods The radiation dose (0.075,0.5,2.0 Gy), the constant dose rate (0.5 mGy / min), the low, medium and high doses of ~ (60) Co- One-time irradiation of mice, ELISA detection of plasma IL-12 and IL-10 levels after 4h. RESULTS: The levels of IL-12, IL-10 and IL-12 / IL-10 in plasma were almost the same after low and medium doses of irradiation; however, the levels of IL-12 were further significantly decreased and the levels of IL-10 To the control group, IL-12 / IL-10 ratio decreased further. CONCLUSION: The radiation dose of ~ (60) Co-γ at a dose rate of 0.5 mGy / min can damage the immune function of human body. The damage is slight in the dose range of 0.075-0.5Gy and the damage is obvious at 2.0Gy. Rate ionizing radiation has damaging effects on the immune system.