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研究低硒（Ｓｅ）低维生素Ｅ（ＶＥ）膳食及补充Ｓｅ和ＶＥ后对大鼠心肌腺苷酸含量和氧化损伤的关系。方法：采用高效液相和生化方法分别测定心肌腺苷酸和ＭＤＡ含量、ＳＯＤ、ＧＳＨ－Ｐｘ活性。结果：与补充Ｓｅ和／或ＶＥ饮食大鼠相比，低Ｓｅ低ＶＥ饮食大鼠心肌ＡＭＰ、ＡＤＰ含量无明显差异，而ＡＴＰ含量明显降低，ＭＤＡ含量增加，ＳＯＤ、ＧＳＨ－Ｐｘ活性降低，表明Ｓｅ和ＶＥ影响ＡＴＰ含量与其抗氧化作用有关，而其中以联合补充Ｓｅ和ＶＥ效果最佳。结论：Ｓｅ和ＶＥ缺乏可使心肌呈现明显的氧化损伤，补充Ｓｅ和ＶＥ有助于抗氧化损伤，使ＡＴＰ生成增加。
To study the effect of low selenium (Se) vitamin E (VE) diet and Se and VE supplementation on myocardial adenosine content and oxidative damage in rats. Methods: Adenosine and MDA content, SOD, GSH-Px activity were measured by HPLC and biochemical methods respectively. Results: Compared with Se and / or VE-supplemented rats, the levels of AMP and ADP in myocardium of low-Se-low-VE diet rats were not significantly different, while the content of ATP was significantly decreased, the content of MDA was increased and the activities of SOD and GSH-Px were decreased The effect of Se and VE on ATP content is related to its anti-oxidant effect, and the combination of Se and VE is the best. Conclusion: The lack of Se and VE can make the myocardium show obvious oxidative damage. Se and VE are supplemented to help prevent oxidative damage and increase the production of ATP.