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目的分析云南省保山市美沙酮维持治疗(MMT)吸毒人群丙型病毒性肝炎(丙肝)病毒(HCV)抗体阳转影响因素。方法 2015年7月采用抽样调查的方法对MMT有丙肝检测记录且第一次HCV抗体阴性的吸毒人员进行问卷调查和血清学检测,同时抽取5 ml静脉血进行HCV抗体检测,分析抗体阳转情况及影响因素。使用EpiData 3.0软件建立数据库,SPSS 19.0软件处理数据和统计分析。结果 MMT吸毒人群HCV抗体累计阳转率17.00%(34/200),观察人年发病密度为30.36%(34/112);HCV抗体阳转者和未阳转者丙肝知晓率分别为70.59%(24/34)和52.40%(87/166),差异无统计学意义(χ~2=3.776,P=0.052)。非条件logistic回归分析显示,注射吸毒行为(OR=1.807,95%CI:1.000~2.460,P=0.001)和嗜酒(OR=2.749,95%CI:1.181~6.398,P=0.019)是HCV抗体阳转的促进因素。结论 MMT吸毒人群HCV抗体阳转率高,阳转时间短,要加强注射吸毒者和嗜酒吸毒者的健康教育和行为干预。
Objective To analyze the influencing factors of positive conversion of hepatitis C virus (HCV) to methadone maintenance treatment (MMT) drug users in Baoshan, Yunnan Province. Methods In July 2015, a questionnaire survey and serological test were conducted on patients with MMT who had hepatitis C test records and the first HCV antibody negative by sampling method. Meanwhile, 5 ml of venous blood was taken for HCV antibody detection, And influencing factors. Database was created using EpiData 3.0 software, SPSS 19.0 software to process data and statistical analysis. Results The cumulative positive rate of HCV antibody in MMT drug users was 17.00% (34/200), and the annual incidence of HCV infection was 30.36% (34/112). The HCV prevalence of positive and negative HCV antibody recipients was 70.59% 24/34) and 52.40% (87/166) respectively, with no significant difference (χ ~ 2 = 3.776, P = 0.052). Non-conditional logistic regression analysis showed that the drug-taking behaviors (OR = 1.807, 95% CI: 1.000-2.460, P = 0.001) and alcohol abuse (OR = 2.749,95% CI: 1.181-6.398, P = 0.019) Positive rotation of the promotion factor. Conclusion The HCV antibody positive rate of MMT drug addicts is high, and the positive rotation time is short. Health education and behavioral intervention of injecting drug users and alcohol addicts should be strengthened.