透射电镜观察到丙硫咪唑治疗后绵羊原发性细粒棘球蚴囊壁角质层疏松,局域性坏死;生发膜皮层区微绒毛脱落或消失,远端胞浆中出现巨大空泡;生发膜细胞胞浆疏松,细胞器排列紊乱,微管局限性扩张、破裂,线粒体空泡化,高尔基复合体解体,核膜完整性受损,溶酶体增大、增多。提示丙硫咪唑对绵羊原发性细粒棘球蚴有广泛的细胞内效应。 TEM observation showed that after the treatment with althiazole, sheep stratum corneum of primary Echinococcus granulosus loose, localized necrosis; microvilli shedding or disappearing in the cortical area of ​​hair cells, and large vacuoles appeared in the distal cytoplasm; Membrane cytoplasm loose, disorganized organelles, local expansion and rupture of microtubules, mitochondria vacuolization, disintegration of the Golgi complex, damaged nuclear membrane integrity, increased lysosomes and increased. Tip albendazole sheep primary Echinococcus granulosus has a wide range of intracellular effects.