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β-ａｒｒｅｓｔｉｎ -２蛋白是一种调控Ｇ蛋白耦联受体脱敏感化的蛋白质。最新研究表明 ,β-ａｒｒｅｓｔｉｎ -２基因敲除小鼠在长期用药后不产生吗啡耐受 ,提示吗啡耐受与β-ａｒｒｅｓｔｉｎ -２蛋白介导的 μ 阿片受体脱敏感化有关。吗啡是临床上常用的强效镇痛药 ,但是长
Beta-arrestin-2 protein is a protein that regulates the desensitization of G protein-coupled receptors. Recent studies show that β-arrestin-2 knockout mice do not produce morphine tolerance after prolonged administration, suggesting that morphine tolerance is associated with β-arrestin-2 protein-mediated μ opioid receptor desensitization. Morphine is a clinically potent analgesic, but long