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贫血的机理已知,构成ESRD贫血的主要机理为红细胞存活期缩短、红细胞生成素(EP)产生减少及ESRD抑制红细胞生成的抑制物或毒性代谢产物的滞留。其他认可的损害,骨髓功能的可能并发症有铁或叶酸盐缺乏,铝中毒及甲旁亢伴有的纤维性骨炎。 ESRD透析病人用~(51)Cr、DF~(32)P、~(14)C-氰酸盐标记的同位素红细胞及测定CO呼出证实红细胞存活期缩短。CO呼出测定法的应用,对其判断十分敏感。因一个血红素分子破坏就释放一个分子的CO。一般ESRD合并溶血并不严重。红细胞存活期从
The mechanism of anemia is known and the main mechanisms that make up ESRD anemia are shortened survival of erythrocytes, reduced production of erythropoietin (EP), and retention of inhibitors or toxic metabolites of ESRD to inhibit erythropoiesis. Other recognized damage, possible complications of bone marrow function are iron or folate deficiency, aluminum poisoning and paracolitis accompanied by fibrous osteitis. ESRD dialysis patients with ~ (51) Cr, DF ~ (32) P, ~ (14) C-cyanide labeled isotope erythrocytes and measured CO exhaled confirmed survival of shortened erythrocytes. The application of CO exhalation assay is very sensitive to its judgment. One molecule of CO is released by the destruction of one heme molecule. General ESRD combined hemolysis is not serious. Erythrocyte survival from