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目前,在各种节育措施中,宫内节育器(IUD)的使用比较普遍,但由于存在某些副反应,特别是带IUD 后经量增多而因症取出,使IUD 的使用受到一定限制。IUD 引起经量增多的机理各国学者进行了大量的研究,但众说纷纭。很多学者认为是由于IUD 引起子宫内膜纤溶活性增加所致。在正常月经周期中,子宫内膜的纤溶活性存在着周期性变化,分泌期较增殖期高,于月经前期达最高值。这可能是预防大血块的形成及使子宫腔内已形成的血块重溶,以便经血流出宫腔,这是一种受激素调节的生理现象。人类子宫液的纤溶活性也有周期性的变化,但与子宫内膜不同,在增殖期纤维蛋白溶解活性
At present, the use of intrauterine devices (IUDs) is common in various types of birth control measures. However, the use of IUDs is limited due to the presence of certain side effects, particularly those with IUDs. IUD caused by the mechanism of increased volume of scholars from all over the world a lot of research, but different opinions. Many scholars believe that due to IUD caused by increased fibrinolytic activity of the endometrium. In the normal menstrual cycle, fibrinolytic activity of the endometrium there is a cyclical change, the secretory phase higher than the proliferative phase, reaching the highest value in the premenstrual period. This may be to prevent the formation of large blood clots and the formation of the uterine cavity has been re-dissolved in order to blood flow out of the uterine cavity, which is a hormone-regulated physiological phenomenon. Fibrinolytic activity of human uterine fluid also has periodic changes, but unlike the endometrium, proliferating fibrinolytic activity