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近来作者曾报导LRF及LRF高活性类似物[D-色~6脯,~9NEt]-LRF(LRF-Ag),在妇女可诱发黄体溶液。并曾注意到LRF的黄体溶解作用,在早期黄体期使用似乎效果较小。本文目的系通过研究LRF作诱发黄体溶解使用确切时间,重现性,可逆性,以评价临床实用价值。15名自愿者,月经周期规则,年龄25～39岁。所有对象未用过激素避孕药,平均周期长28天,每例均测基础体温(BBT),每周期第10天开始系统测定血中黄体生成素(LH),孕酮(p),雌二醇(E_2)以监测月经周期。对照周期以后,15例于黄体期注射LRF50μg1或2天,血液标本每例每天在上午8～10点采取。在BBT双相后的不同时间开始注射LRF-Ag。15例参加治疗1～4个周期。14名妇女做了治疗后
Recently, the authors have reported that LRF and LRF highly active analogue [D-6B-9NEt] -LRF (LRF-Ag) can induce luteal solution in women. It has also been noted that luteal lysis of LRF appears to be less effective in the early luteal phase. The purpose of this paper is to study the LRF induced luteal lysis using the exact time, reproducibility, reversibility, to evaluate the clinical value. 15 volunteers, menstrual cycle rules, aged 25 to 39 years old. All subjects had no hormonal contraceptives, the average period of 28 days, basal body temperature (BBT) were measured in each case, the first 10 days of each cycle began to determine the serum levels of luteinizing hormone (LH), progesterone (p), estrogen Alcohol (E_2) to monitor the menstrual cycle. After the control period, 15 cases were injected with LRF 50 μg for 1 or 2 days in the luteal phase, and blood samples were taken daily at 8-10 in the morning. Injection of LRF-Ag began at different times after biphasic BBT. 15 cases participated in the treatment of 1 to 4 cycles. After 14 women were treated