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中华猕猴桃多糖是一种生物反应调节剂。本文研究了它的制剂(ABS)对T淋巴细胞的调节功效。ABS在体外用~3H-TdR掺入法证明能刺激小鼠脾淋巴细胞,特别是胸腺细胞的增殖,呈倒钟罩型剂量依赖关系曲线。最适浓度为50μg/ml。进一步研究显示,腹腔给予剂量为6mg及24mg/kg后能增进小鼠脾淋巴细胞分泌白细胞介素2(IL-2),其中6ma/kg剂量组脾细胞IL-2活性比对照组提高265%,高峰在停药后第6天。给慢性迁延型肝炎患者肌肉注射ABS(4～8mg/日)后,看到其外周血T_4淋巴细胞百分比及T_4/T_8比例得以提高。本文研究提示ABS的免疫调节作用与诱导T_4淋巴细胞並产生IL-2有关。
Actinidia chinensis polysaccharide is a biological response modifier. This article studied the effect of its preparation (ABS) on the regulation of T lymphocytes. ABS in vitro with ~3H-TdR incorporation method proved to stimulate the proliferation of mouse spleen lymphocytes, especially thymocytes, showing an inverted bell-shaped dose-dependent curve. The optimal concentration is 50 μg/ml. Further studies showed that intraperitoneal administration of 6 mg and 24 mg/kg could increase the secretion of interleukin-2 (IL-2) from spleen lymphocytes of mice, of which IL-2 activity in spleen cells at 6ma/kg increased by 265% compared with the control group. The peak was on the 6th day after drug withdrawal. After intramuscular injection of ABS (4 to 8 mg/day) in patients with chronic persistent hepatitis, the percentage of T_4 lymphocytes and T_4/T_8 ratio in peripheral blood were increased. This study suggests that the immunoregulatory effects of ABS are related to the induction of T4 lymphocytes and the production of IL-2.