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目的比较布地奈德混悬液阶梯雾化吸入和布地奈德气雾剂+贮雾罐吸入治疗婴幼儿哮喘的效果,为改善婴幼儿哮喘提供依据。方法 106例哮喘婴幼儿随机分为观察组和对照组,各53例。观察组采用布地奈德混悬液阶梯雾化吸入方案;对照组采用布地奈德气雾剂+贮雾罐吸入治疗。在入院时,治疗12、24、28周时进行症状评分,并在48周随访结束时,统计患儿吸入依从率、发作就医次数、发作总天数、缓解期药物用量。结果两组经治疗,症状评分均较入院时显著改善,差异具有统计学意义(P<0.05)。其中:观察组治疗12、24、48周时症状评分分别为(0.63±0.35)、(0.61±0.32)、(0.52±0.36)分,均显著低于对照组(t值分别为6.436、6.418、6.835,P<0.05)。观察组依从率为94.34%,显著高于对照组77.36%(P<0.05)。观察组发作就医次数、发作总天数、缓解期药物使用量分别为(2.2±1.4)次、(12.8±6.5)d、(0.18±0.13)mg/d,均显著低于对照组(P<0.05)。结论阶梯雾化吸入可以显著改善婴幼儿哮喘的症状评分,提高患儿的依从率,减少治疗期间发作次数和发作天数,并减低布地奈德的使用量,是目前临床上治疗婴幼儿哮喘的一种相对理想的方法。
Objective To compare the effect of inhalation of Budesonide suspension ladder inhalation and budesonide aerosol + storage tank inhalation on infant asthma, so as to provide basis for improving infant asthma. Methods 106 cases of asthma infants and young children were randomly divided into observation group and control group, 53 cases each. In the observation group, budesonide suspension step aerosol inhalation was used; in the control group, budesonide aerosol + aerosol canister was used for inhalation. At the time of admission, symptom scores were obtained at 12, 24, and 28 weeks of treatment. At the end of the 48-week follow-up, statistics were made on the rate of children’s compliance with inhalation, the number of seizures, the total number of days of attack, and the amount of drug used during remission. Results After treatment, the scores of symptoms in both groups were significantly improved as compared with admission, the difference was statistically significant (P <0.05). The scores of symptoms in observation group were (0.63 ± 0.35), (0.61 ± 0.32) and (0.52 ± 0.36) points respectively at 12, 24 and 48 weeks after treatment, which were significantly lower than those in control group (t = 6.436,6.418, 6.835, P <0.05). The compliance rate of the observation group was 94.34%, which was significantly higher than that of the control group (77.36%, P <0.05). The incidence of medical treatment in the observation group was (2.2 ± 1.4) times, (12.8 ± 6.5) days and (0.18 ± 0.13) mg / d, respectively, which were significantly lower than those in the control group (P <0.05) ). Conclusion Step-atomization inhalation can significantly improve infant asthma symptom score, improve children’s compliance rate, reduce the number of attacks during the treatment and the number of seizures days, and reduce the use of budesonide, is currently the treatment of asthma in infants and young children A relatively ideal method.