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人体血清AP数值的升高常见于梗阻性黄疸以及几种小肠和胎盘的疾病,骨病如骨纤维发育异常、骨折和骨髓炎均见AP值升高,在骨肉瘤AP值亦可升高。本文报告1975年1月～1977年8月间收治的30例骨肉瘤患者,男25例,女5例;年龄10～47岁(平均18岁,中位19岁)。均无临床转移并行完全切除。术后俟伤口愈合便给予辅助化疗。方法是:氨甲喋呤50mg/kg静脉滴人。历时6小时以上,然后给予四氢叶酸15mg/m~2。每6小时一次静脉注射或肌肉注射,共给48小时。氨甲喋呤剂量逐步上升到最大一次量250mg/kg,有些病人在给氨甲喋呤之前30分钟时静脉注射长春新碱2mg/m~2。所有病人均在术前以及术后每隔3周测量AP数值。
Increases in human serum AP levels are common in obstructive jaundice and several small intestine and placental diseases. Bone disease such as dysplasia of bone fibers, fractures, and osteomyelitis all have elevated AP values, and AP values may also increase in osteosarcoma. This article reports 30 cases of osteosarcoma treated between January 1975 and August 1977, 25 males and 5 females; aged 10 to 47 years (mean 18 years, median 19 years). No clinical metastasis was completely removed in parallel. Adjuvant chemotherapy was given after wound healing. Method is: methotrexate 50mg/kg intravenously. After more than 6 hours, tetrahydrofolate 15 mg/m~2 was given. Intravenous injection or intramuscular injection every 6 hours for a total of 48 hours. The dose of methotrexate gradually increased to a maximum of 250 mg/kg, and some patients intravenously injected vincristine 2 mg/m 2 30 minutes before methotrexate. All patients measured AP values before surgery and every 3 weeks after surgery.