论文部分内容阅读
目的制备斑蝥素β-环糊精包合物,以达到提高药物水溶性和减少黏膜刺激性的目的。方法采用饱和水溶液法制备包合物,采用显微镜、TLC和DSC对包合物进行验证。测定包合前后斑蝥素的水中溶解度。考察包合前后斑蝥素对大鼠胃黏膜的刺激性。结果制备了斑蝥素β-环糊精包合物。斑蝥素的溶解度较包合前提高了11.8倍。包合物未见黏膜刺激。结论斑蝥素制成包合物可以达到提高药物水溶性和减少药物黏膜刺激性的目的。
Objective To prepare cantharidin β-cyclodextrin inclusion complex in order to improve the water-solubility of drugs and reduce the irritation of mucosa. Methods The inclusion complex was prepared by saturated aqueous solution. The inclusion complex was verified by microscope, TLC and DSC. Determination of water solubility of cantharidin before and after inclusion. To investigate the irritation of rat gastric mucosa before and after inclusion of cantharidin. As a result, cantharidin β-cyclodextrin inclusion compound was prepared. The solubility of cantharidin increased by 11.8 times compared with that before inclusion. Inclusion compound no mucous membrane stimulation. Conclusion The inclusion of cantharidin can improve the water solubility of drugs and reduce the irritation of the drug mucosa.