Objective: To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma.Methods: Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic body radiotherapy.Planning of treatment was made and the prescribed dose was adjusted depending on the site of the tumor, clinical target volume (GTV), Kanofsky Performance and aim of treatment. Planning target volume received 50%-80% of the prescribed dose for 3.2-4.2 Gy per-fraction. Treatment total dose was 32-42 Gy (median dose 40 Gy) in daily fractions of 3.2-4.2 Gy for five fractions one week. Results: All the patients completed the planned radiotherapy. The tumor response rate was CR 25.9%, PR 55.6%, NR 18.59%; the response rate (CR + PR) was 81.5%. Half-year local recurrence-free survival rate was 75%; 1-year local recurrence-free survival rate was 22%. There were no serious complications during radiotherapy and follow-up. Pain relieve rate in liver region was 83.3%. Conclusion: Stereotactic body radiotherapy can improve the local control and quality of life on the treatment of primary hepatic neoplasm while not increasing the treatment complication.