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目的探讨奥扎格雷钠治疗急性脑梗死的临床疗效及对患者血浆炎性因子水平的影响。方法将56例急性脑梗死患者随机分为治疗组和对照组,各28例。治疗组在常规治疗的基础上给予奥扎格雷钠静脉滴注,同时口服阿司匹林,对照组在常规治疗基础上仅给予阿司匹林口服,两组均连续治疗2周后进行疗效评价;于治疗前后分别测定患者血浆炎性因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平。结果治疗组痊愈率为39.28%,总有效率为92.86%;对照组痊愈率为21.43%,总有效率为78.57%,治疗组的痊愈率和总有效率均明显高于对照组,具有统计学意义(P<0.05)。治疗2周后,两组血浆IL-6、IL-8、TNF-α水平均较本组治疗前明显降低,其中治疗组有极显著性差异(P<0.01),对照组有显著性差异(P<0.05);治疗后,治疗组血浆IL-6、IL-8、TNF-α水平均明显低于对照组(P<0.05)。结论奥扎格雷钠治疗急性脑梗死临床疗效确切,可显著降低患者神经功能缺损评分,较好的恢复神经功能,值得临床推广应用。
Objective To investigate the clinical efficacy of ozagrel sodium in the treatment of acute cerebral infarction and its effect on plasma levels of inflammatory cytokines. Methods 56 cases of acute cerebral infarction were randomly divided into treatment group and control group, 28 cases in each. The treatment group was given Ozagrel sodium intravenously on the basis of routine treatment, while aspirin was given orally. In the control group, only aspirin was given orally on the basis of conventional treatment. The curative effect was evaluated after two weeks of continuous treatment in both groups. Before and after treatment, The plasma levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were measured. Results The cure rate of the treatment group was 39.28%, the total effective rate was 92.86%. The cure rate of the control group was 21.43%, the total effective rate was 78.57%. The cure rate and total effective rate of the treatment group were significantly higher than that of the control group Significance (P <0.05). After 2 weeks of treatment, the levels of plasma IL-6, IL-8 and TNF-α in both groups were significantly lower than those before treatment in the two groups (P <0.01), and there was significant difference in the control group P <0.05). After treatment, the levels of plasma IL-6, IL-8 and TNF-α in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Ozagrel sodium in the treatment of acute cerebral infarction clinical efficacy is exact, can significantly reduce the patient’s neurological deficit score, better recovery of nerve function, worthy of clinical application.