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目的了解胎儿肝脏的发育状况，探讨肝细胞与造血灶之间的关系。②方法选用２４例不同发育时期的胎儿，进行组织学、形态计量学和超微结构观察。③结果随胚龄增长胎儿肝细胞数量增多，体积增大，核质比减小，细胞器渐丰富；细胞排列有序且始终有明、暗细胞之分。肝血窦腔隙开始较大，造血组织在胚胎早中期较丰富；胚胎发育后期，肝血窦渐变窄，造血组织明显减少。胆小管发育至胚胎晚期，封闭其管腔的紧密连接发育完善。④结论肝细胞发育过程中始终有明、暗肝细胞之分。胎儿肝脏在胚胎早期和中期均有造血功能。发育中的肝细胞及库普弗细胞与幼红细胞密切接触，可能为造血细胞的发育提供良好的微环境。
Objective To understand the development of fetal liver and explore the relationship between hepatocytes and hematopoietic foci. Methods 24 fetuses of different developmental stages were selected for histological, morphometric and ultrastructural observation. ③ results with the growth of embryonic age fetal liver cells increased, the volume increases, the ratio of nuclear to reduce, organelles gradually rich; cells arranged in an orderly and always have bright and dark cells. Hepatic sinusoid lacunar begins larger, hematopoietic tissue in early embryonic metaphase more abundant; late embryonic development, sinusoidal sinus narrowing, hematopoietic tissue was significantly reduced. The development of the bile duct to the late embryo, closing the tight connection of its lumen developed. ④ Conclusion There are always bright and dark hepatocytes in the process of hepatocyte development. Fetal liver in the early and mid embryo hematopoietic function. Developing hepatocytes and Kupffer cells are in close contact with erythroblasts and may provide a good microenvironment for the development of hematopoietic cells.