近年来,抗生素的进展颇大,各种感染性疾病的治疗及预防都离不开抗生素的应用,然而其副作用也不少,其中之一是由于抗生素的作用抑制了肠内产生维生素K的菌群,结果发生出血倾向。此种出血倾向,是由肝脏产生的凝血因子中,第Ⅱ、Ⅶ、Ⅸ、Ⅹ等四种凝血因子,即依赖维生素K的凝血因子减少所致。本文就抗生素应用时,并用与不并用维生素K,观察对凝血机能的影响。作者从1984年3月至1985年2月,将应用抗生素的患者 In recent years, the progress of antibiotics, a variety of infectious diseases treatment and prevention are inseparable from the application of antibiotics, but its side effects are also many, one of which is due to the role of antibiotics inhibit the production of vitamin K in the intestine Group, the result bleeding tendency. This bleeding tendency, is produced by the liver clotting factor, Ⅱ, Ⅶ, Ⅸ, X and other four kinds of clotting factor, that is dependent on the reduction of vitamin K-induced coagulation factors. In this paper, the application of antibiotics, with and without vitamin K, to observe the impact on the coagulation function. The author will apply antibiotics to patients from March 1984 to February 1985