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目的研究脑梗死(CI)及多梗死性痴呆(MID)患者血清高迁移率蛋白-1(HMGB1)、神经元特异性烯醇化酶(NSE)含量的变化及意义。方法采用ELISA法对72例CI及60例MID患者血清中HMGB1、NSE含量进行测定,MID患者的智能水平采用简易智能量表(MMSE)测定,并参考Hachinski缺血评分及DSM-Ⅳ诊断标准进行确诊。结果 CI急性期组患者血清HMGB1、NSE浓度明显高于对照组(P<0.01);而CI恢复期组患者血清HMGB1、NSE的浓度与对照组差异无统计学意义(P>0.05);MID患者HMGB1浓度与对照组及CI恢复期组之间差异无统计学意义(P>0.05);而NSE浓度低于对照组及CI恢复期组(P<0.05)。结论 HMGB1、NSE可反映MID患者脑神经细胞、神经胶质细胞的损害情况和功能状态,对MID患者的病情及预后判断有重要意义。
Objective To study the changes and significance of serum high mobility group-1 (HMGB1) and neuron specific enolase (NSE) in patients with cerebral infarction (CI) and multi-infarct dementia (MID) Methods Serum levels of HMGB1 and NSE in 72 patients with CI and 60 patients with MID were determined by ELISA. The intelligence level of MID patients was measured by MMSE and Hachinski’s ischemic score and DSM-Ⅳ diagnostic criteria Confirmed. Results Serum levels of HMGB1 and NSE were significantly higher in acute CI patients (P <0.01), while serum levels of HMGB1 and NSE in CI patients were not significantly different from those in control group (P> 0.05) There was no significant difference between HMGB1 concentration and control group and CI recovery group (P> 0.05), while NSE concentration was lower than that of control group and CI recovery group (P <0.05). Conclusion HMGB1 and NSE can reflect the damage and functional status of brain neurons and glial cells in patients with MID, which is of great significance for the prognosis and prognosis of MID patients.