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具有抗微生物作用的避孕产品可以用来降低或消除人类获得性免疫缺陷病毒(HIV)和其它性传播疾病(STD)发生的危险性,并可防止意外妊娠的发生。基于这样的一种假设,即引起STD的一些微生物和精子受精可能具有相同的结合和进入宿主细胞机制,高分子量聚4-苯乙基磺酸钠(T-PSS)为一种非细胞毒性介质,可同时阻止STD感染和精于受精。2％或5％的T-PSS凝胶可完全阻止精子受精,将其放置在阴道后可迅速扩散并通过阴道黏膜起效。T-PSS的避孕效果并不是由于对精子具有细胞毒性或限制精子移动造成,而是因为它可以抑制透明质酸酶(IC_(50)=5.3 μg/ml)、顶体蛋白(IC_(50)=
Anti-microbial contraceptive products can be used to reduce or eliminate the risk of developing human acquired immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs) and to prevent the onset of unwanted pregnancies. Based on the hypothesis that some microorganisms that cause STDs and sperm fertilization may have the same mechanism of binding and entry into the host cell, high molecular weight sodium poly-4-phenylpropionate (T-PSS) is a non-cytotoxic mediator , Can both prevent STD infection and be good at fertilization. T-PSS gels, 2% or 5%, completely prevent sperm from being fertilized, allowing them to spread quickly and vaginally when placed in the vagina. The contraceptive effect of T-PSS is not due to cytotoxicity to sperm or restriction of sperm motility, but because it inhibits hyaluronidase (IC 50 = 5.3 μg / ml), acrosin (IC 50) =