目的:探索观察全麻复合硬膜外麻醉对胃癌根治术患者血浆内皮素、一氧化氮及血流动力学的影响。方法:选取2010年1月~2012年12月于我院行胃癌根治术患者40例随机分成单纯全麻(A)和全麻联合硬膜外阻滞(B)2组,分别于麻醉前(T1)、麻醉后30分钟(T2)、术毕(T3)采集外周静脉血进行检测血浆内皮素、一氧化氮及血流动力学的变化。结果:A组NO,ET~1浓度T3比T1、T2降低(P<0.05)B组NO浓度升高,ET-1浓度降低(P<0.05)。(2)B组NO较A组高,B组ET-1较A低,A组血流动力学变化明显高于B组。结论:全麻联合硬膜外麻醉可减轻胃癌根治术患者术后的应激反应和免疫功能的抑制,在一定程度上能保持细胞因子的相对平衡,有利于患者的术后康复甚至于远期生存,为该手术较合适的麻醉方法。 Objective: To investigate the effects of general anesthesia combined with epidural anesthesia on plasma endothelin, nitric oxide and hemodynamics in patients undergoing gastric cancer radical operation. Methods: Forty patients with radical gastrectomy undergoing radical gastrectomy in our hospital from January 2010 to December 2012 were randomly divided into two groups: general anesthesia (A) and general anesthesia combined with epidural block (B) T1), 30 min after anesthesia (T2), and peripheral venous blood (T3) were collected to detect plasma endothelin, nitric oxide and hemodynamic changes. Results: The concentrations of NO and ET-1 in group A were lower than those in groups T1 and T2 (P <0.05). The concentration of NO and the concentration of ET-1 in group B were decreased (P <0.05). (2) NO in group B was higher than that in group A, while ET-1 in group B was lower than that in group A. The hemodynamic changes in group A were significantly higher than those in group B. Conclusion: General anesthesia combined with epidural anesthesia can reduce postoperative gastric cancer radical response and immune suppression, to a certain extent, can maintain the relative balance of cytokines, is conducive to the patient’s postoperative recovery even in the long term Survival, for the surgery more appropriate method of anesthesia.