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系统性红斑狼疮(SLE)是一种以B细胞反应过强为特征的自身免疫性疾病,由于缺乏调节细胞群而使产生自身抗体的B 细胞克隆脱离了正常过程。曾有人报道,SLE 病人的IL-2产生和反应缺陷,尤其是活动性SLE 更为显著,这些异常或许会导致病人的抑制作用缺陷。这种抑制作用可能反映SLE病人的B 细胞反应过强而致的免疫调节异常,因此作者通过对正常人及SLE 病人的PBL 的细胞介素分析,进一步研究了对IL-6反应的抑制作用。
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an over-reaction of B-cells that leaves auto-antibody-producing B-cell clones out of the normal process due to a lack of regulatory cell population. It has been reported, SLE patients IL-2 production and response to defects, especially active SLE more significantly, these abnormalities may lead to defects in the inhibition of the patient. This inhibitory effect may reflect an abnormal immunomodulatory response of B cells in SLE patients. Therefore, the authors further investigated the inhibitory effect on IL-6 response by analyzing the cytoskeleton of PBL in normal and SLE patients.