论文部分内容阅读
给200g 左右的大鼠腹腔注射γ-氨基丁酸(GABA)合成和释放抑制剂3-巯基丙酸(3MP)25、20和10mg/kg,可以加强电针和吗啡的镇痛作用。这种加强作用可被 GABA 降解酶抑制剂氨氧乙酸(AOAA)所对抗。腹腔注射 AOAA 25mg/kg 能提高脑内 GABA 含量,同时降低电针和吗啡的镇痛作用,这种降低作用可被 GABA 合成酶抑制剂异烟肼和 GABA 受体阻断剂氯甲基荷包牡丹碱所对抗。这些实验结果表明,脑内 GABA 能系统对于电针和吗啡镇痛具有对抗作用。文中讨论了 GABA 上述作用的可能机理。
Giving 200 g of rat intraperitoneal injection of γ-aminobutyric acid (GABA) at 25, 20 and 10 mg / kg, an inhibitor of 3-mercaptopropionic acid (3MP), potentiated the analgesic effect of electroacupuncture and morphine. This potentiation can be countered by the GABA-degrading enzyme inhibitor AOAA. Intraperitoneal injection of AOAA 25mg / kg can increase brain GABA levels, while reducing the electroacupuncture and morphine analgesic effect, this reduction can be GABA synthase inhibitor isoniazid and GABA receptor blocker chloromethyl pupa peony Alkali confrontation. These experimental results show that the brain GABAergic system has antagonistic effects on EA and morphine analgesia. This paper discusses the possible mechanism of GABA action.