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自从淋巴细胞杂交瘤1975年创立以来,在实际应用中越来越显出其优越性。由于鼠源性单克隆抗体在临床上应用往往引起过敏反应或形成免疫复合物,因而科学家们在研究人—人杂交瘤。目前,世界上有三个人—人杂交瘤系统:(1)Olsson和Kaplan等培育的SKO-007骨髓瘤细胞系统,(2)Croce等培育的GM1500B骨髓瘤细胞系统,(3)Clark等培育
Since the establishment of lymphocyte hybridoma in 1975, it has become more and more obvious in practical application. Because murine monoclonal antibodies often cause allergic reactions or form immune complexes in clinical use, scientists are investigating human-human hybridomas. Currently, there are three human-human hybridoma systems in the world: (1) SKO-007 myeloma cell system cultivated by Olsson and Kaplan, (2) GM1500B myeloma cell system cultivated by Croce et al, and (3)