系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种全身性免疫性疾病,绝大多数在妊娠期出现活动。过去因其导致严重母婴并发症而选择避免怀孕。近年来随着对SLE更深入研究和多学科综合治疗,使本病预后明显改善[1]。严重狼疮活动和皮质醇使用可导致早产、胚胎或胎儿死亡。不良妊娠预后发生率高达76%[2-4]。本文综述妊娠合 Systemic lupus erythematosus (SLE) is a systemic immune disease, the vast majority of activities occur during pregnancy. In the past, they chose to avoid pregnancy because of their serious maternal and child complications. In recent years, with more in-depth study of SLE and multidisciplinary treatment, so that the prognosis of the disease significantly improved [1]. Severe lupus activity and cortisol use can result in premature birth, embryo or fetal death. Prognosis of adverse pregnancy as high as 76% [2-4]. This article reviews gestational age