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孕激素一雌激素联合口服避孕药已广泛用作有效的生育控制剂。自1960年引用以来,人们一直在努力为制定一种激素剂量小、副作用最少而避孕效果又好的口服避孕药配方,因此,从惯用的固定剂量配方发展成双相(分两阶段)口服避孕药,近来又发展了三相口服避孕药,各个不同剂量的配方以分段的型式给予、类固醇的量与月经周期的激素波动大致相符。对29例正常健康妇女给予ORTHO7/7/7三相口服OC,研究其对垂体和卵巢功能的抑制作用。该配方含有同一低剂量的乙炔雌二醇(EE)和以7天为期逐步增加剂量的炔诺酮(NE),共
Progesterone-estrogen combined with oral contraceptives has been widely used as an effective fertility control agent. Since 1960, there has been an ongoing effort to develop an oral contraceptive formulation with low hormonal doses and minimal side effects and good contraceptive efficacy. Therefore, the development of dual-phase (two-phase) oral contraceptives from conventional fixed-dose formulations Recently, three-phase oral contraceptives have also been developed. Each of the different doses of the formulation is given in a segmented fashion. The amount of steroids roughly corresponds to the hormonal fluctuations of the menstrual cycle. Twenty-nine normal healthy women were given ORTHO7 / 7/7 three-phase oral OC to study its inhibitory effect on pituitary and ovarian function. The formula contains the same low dose of ethinyl estradiol (EE) and a gradually increasing dose of norethindrone (NE) for a period of 7 days for a total of