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反流性食管炎(RE)是指由于胃和(或)十二指肠内容物反流入食管,引起食管粘膜损害,即患者不仅有胃食管反流(GER),食管还存在炎性损害.原发性食管胃肠运动功能障碍是引起胃食管反流病(GERD)的主要原因.食管运动功能与GERP 密切相关,其中 LES 和食管的清除功能最为重要,其他如 His 角,胃斜行肌、隔肌食管韧带等也具有防反流的作用.LES 静止压,低于10mmmHg 时,出现 GER 的可能性大,胃伸展扩张的刺激和胃排空延迟均可引起一过性 LES 弛缓,使食管酸暴露时间延长,一过性 LES 弛缓是发生 GER 的主要机制,RE患者中2/3是因 LES 一过性弛缓所致,一过性弛缓时间可达10S以上或持续超过30s.有关食管胃肠运动能方面研究的报
Reflux esophagitis (RE) refers to the esophageal mucosa that is caused by the backflow of gastric and / or duodenal contents into the esophagus, ie, the patient has not only gastroesophageal reflux (GER) but also inflammatory lesions in the esophagus. Primary esophageal gastrointestinal motility disorder is the main cause of gastroesophageal reflux disease (GERD) Esophageal motility is closely related to GERP, of which LES and esophageal clearance is most important, others such as His angle, gastric oblique , The diaphragm esophageal ligament also has the role of anti reflux.LES static pressure, less than 10mmmHg, the possibility of GER appear large, gastric expansion and contraction of the gastric emptying delay can cause a delayed relaxation of LES, so that Esophageal acid exposure time prolonged transient LES relaxation is the main mechanism of GER occurs in RE patients 2/3 due to a transient relaxation of LES caused by a transient relaxation time of up to 10S or more than 30s. Gastrointestinal motility research report