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为探讨支气管肺泡灌洗液（ＢＡＬＦ）中ＣＤ４／ＣＤ８比率在非何杰金氏病、结节病、结核病三种疾病之间是否有差异，对经病理活检证实的７例非何杰金氏病和６例结节病；经痰菌检查证实的７例结核病和９例健康者进行了支气管肺泡灌洗，并对ＢＡＬＦ中的ＣＤ４＋和ＣＤ８＋细胞进行了分析测定。结果显示：ＢＡＬＦ中ＣＤ４／ＣＤ８比率在非何杰金氏病组中不但显著低于正常对照组，而且显著低于结节病组和结核病组（Ｐ均＜０．０１）；结节病组的ＣＤ４／ＣＤ８比率不但显著高于正常对照组，也显著高于结核病组（Ｐ均＜０．０１）；结核病组ＣＤ４／ＣＤ８比率与正常对照组无明显差异（Ｐ＞０．５）。研究表明，分析ＢＡＬＦ中ＣＤ４／ＣＤ８比率，有助于对表现为双侧纵隔或肺门淋巴结肿大的结节病、非何杰金氏病和结核病等疾病进行鉴别诊断。
In order to investigate whether the ratio of CD4 / CD8 in bronchoalveolar lavage fluid (BALF) is different among the three diseases of non-Hodgkin’s disease, sarcoidosis and tuberculosis, seven cases of non-Hodgkin’s disease confirmed by pathological biopsy And 6 cases of sarcoidosis. Bronchoalveolar lavage was performed on 7 cases of tuberculosis and 9 cases of healthy people confirmed by sputum test, and CD4 + and CD8 + cells in BALF were analyzed. The results showed that the ratio of CD4 / CD8 in BALF was significantly lower in non-Hodgkin’s disease group than in normal control group and significantly lower than those in sarcoidosis and tuberculosis (all P <0.01) (P <0.01). The ratio of CD4 / CD8 in tuberculosis group was not significantly different from that in control group (P> 0.5). Studies have shown that analysis of the CD4 / CD8 ratio in BALF is useful in the differential diagnosis of diseases such as sarcoidosis, non-Hodgkin’s disease and tuberculosis that manifest as enlarged bilateral mediastinal or hilar lymph nodes.