论文部分内容阅读
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种原因不明的间质性肺疾病,其临床治疗效果欠佳。近年来,随着对本病发病机制和病理生理变化的深入研究和分子生物学技术的应用,了解到多种细胞及细胞因子都参与了肺纤维化的发生发展过程。特别是转化生长因子β(TGF-β)及肝细胞生长因子(HGF)在肺纤维化的发病过程中具有重要的作用,治疗上有了新的突破。本文就TGF-β和HGF细胞因子分子机构、功能及在肺纤维化中的治疗作用做一综述。
Idiopathic pulmonary fibrosis (IPF) is an unexplained interstitial lung disease, its poor clinical treatment. In recent years, with the pathogenesis of this disease and pathophysiological changes in-depth study and application of molecular biology techniques, we learned that a variety of cells and cytokines are involved in the occurrence and development of pulmonary fibrosis. In particular, transforming growth factor β (TGF-β) and hepatocyte growth factor (HGF) play an important role in the pathogenesis of pulmonary fibrosis, and new breakthroughs have been made in the treatment. This article reviews the molecular mechanisms of TGF-β and HGF cytokines, their function and their therapeutic effects in pulmonary fibrosis.