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目的观察卡介菌多糖核酸对过敏性鼻炎合并哮喘的临床治疗效果。方法将98例2001年初～2009年初在吉林市中心医院耳鼻喉科就诊的过敏性鼻炎合并哮喘患者随机分为治疗1组、治疗2组及对照组,3组均给予相同的过敏哮喘基础治疗,治疗1组再经肌肉注射卡介菌多糖核酸(BCG polysaccharide and nucleic acid,BCG-PSN)注射液,疗程3个月;治疗2组再经肌肉注射BCG-PSN,疗程6个月;对照组只进行基础治疗,不给予BCG-PSN。观察疗程结束后1年内3组患者过敏性鼻炎及哮喘的发作情况,根据哮喘的发作次数及程度判断疗效。结果疗程结束后0～6个月内,治疗1组和治疗2组的过敏性鼻炎及哮喘的临床症状明显好转,显效率和总有效率均明显高于对照组(P<0.05或P<0.01);疗程结束后7～12个月,治疗2组的显效率和总有效率均明显高于对照组(P均<0.05)。BCG-PSN治疗中未见明显不良反应。结论BCG-PSN治疗过敏性鼻炎合并哮喘疗效确切,安全可靠,远期疗效与疗程有关。
Objective To observe the clinical effect of BCG polysaccharide nucleic acid on allergic rhinitis with asthma. Methods A total of 98 patients with allergic rhinitis and asthma who were treated in otolaryngology department of Jilin Central Hospital from the beginning of 2001 to the beginning of 2009 were randomly divided into treatment group 1, treatment group 2 and control group. All three groups were given the same basic treatment of allergic asthma, The treatment group 1 was injected intramuscularly with BCG polysaccharide and nucleic acid (BCG-PSN) for 3 months. The treatment group 2 was given intramuscular injection of BCG-PSN for 6 months. The control group The basic treatment, not given BCG-PSN. The incidence of allergic rhinitis and asthma was observed in 3 groups within 1 year after the end of treatment, and the curative effect was judged according to the number and extent of asthma attacks. Results The clinical symptoms of allergic rhinitis and asthma in treatment group 1 and treatment group 2 were significantly improved within 0 ~ 6 months after the end of treatment, and both the markedly effective rate and the total effective rate were significantly higher than those in the control group (P <0.05 or P <0.01 ); 7 to 12 months after the end of treatment, the apparent effective rate and total effective rate of treatment group 2 were significantly higher than that of the control group (all P <0.05). BCG-PSN treatment showed no significant adverse reactions. Conclusion BCG-PSN treatment of allergic rhinitis with asthma is effective, safe and reliable, long-term efficacy and course of treatment.