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目的:研究孕妇与新生儿脐带血与对应儿童乙型肝炎病毒标志物的比对分析。方法:选取60例产妇、新生儿脐血以及对应儿童静脉血,利用全自动酶免疫分析仪及人乙型肝炎病毒检测试剂盒进行乙型肝炎病毒标志物检测与对比分析。结果:孕妇、新生儿及对应儿童的HBs Ag阳性率分别为56.7%、53.3%、35.0%,其差异具有统计学意义(P<0.05);孕妇、新生儿及对应儿童的HBe Ag阳性率分别为38.3%、31.7%、13.3%,其差异具有统计学意义(P<0.05)。结论:孕妇与新生儿的乙型肝炎阳性率较为接近,母婴传播明显,经对新生儿治疗干预后对应儿童乙型肝炎阳性率显著降低,因此应及时对孕妇及新生儿进行乙型肝炎治疗干预,降低母婴传播风险。
OBJECTIVE: To compare the umbilical cord blood of pregnant women and newborns with the corresponding hepatitis B virus markers in children. Methods: Sixty cases of maternal and neonatal umbilical cord blood and their corresponding venous blood samples were selected for detection and comparative analysis of hepatitis B virus markers by using automatic enzyme immunoassay analyzer and human hepatitis B virus detection kit. Results: The positive rates of HBsAg in pregnant women, newborns and corresponding children were 56.7%, 53.3% and 35.0%, respectively (P <0.05). The positive rates of HBe Ag in pregnant women, newborns and corresponding children were respectively (38.3%, 31.7%, 13.3%), the difference was statistically significant (P <0.05). Conclusion: The positive rate of hepatitis B in pregnant women and newborns is relatively close, the mother-infant transmission is obvious, and the positive rate of hepatitis B in children corresponding to neonates after treatment is significantly lower, so pregnant women and newborns should be timely treated with hepatitis B Intervention to reduce mother-to-child transmission risk.