为检测山东省中医药研究所研制的解热冲剂在体内外的抑菌作用 ,我们采用了小鼠口服给药保护法 ,测定药物对金黄色葡萄球菌感染小鼠体内的保护效果 ;试管二倍稀释法测定该药对呼吸道致病菌和其它常见致病菌的体外抑菌作用 ,结果表明 :解热冲剂对所试菌均有抑制活性 ,对体内感染金黄色葡萄球菌的小鼠有保护作用 In order to detect the antibacterial effect of antipyretic granules developed in Shandong Institute of Traditional Chinese Medicine in vivo and in vitro, we used the mouse oral administration protection method to determine the protective effect of the drug on mice infected with Staphylococcus aureus; Dilution method was used to determine the antibacterial effect of the drug against respiratory pathogens and other common pathogenic bacteria in vitro. The results showed that: antipyretic granules all have inhibitory activity against the tested bacteria and have protective effect on mice infected with Staphylococcus aureus in vivo.