越来越多的证据表明,线粒体基因突变与各种癌症有关,已在结肠癌、前列腺癌和其他实体肿瘤中发现各种线粒体DNA编码区和调控区突变。研究者首先对前列腺癌上皮细胞进行线粒体DNA片段测序,发现存在多种致病性的线粒体DNA突变,其中细胞色素氧化酶亚单位I(COI)缺失为前列腺癌的普遍特点;继而提取DNA进行COI基因测 There is growing evidence that mitochondrial gene mutations are associated with a variety of cancers and that various mitochondrial DNA coding and control region mutations have been found in colon, prostate and other solid tumors. Researchers first performed sequencing of mitochondrial DNA fragments of prostate cancer epithelial cells and found that there are a variety of pathogenic mitochondrial DNA mutations in which the loss of cytochrome oxidase subunit I (COI) is a common feature of prostate cancer; DNA is subsequently extracted for COI Genomics