氧代卟啉是一种含呋喃环的冠醚,其合成始于一九五○年。Ackman曾用呋喃和丙酮在酸催化下缩合得到二缩合、三缩合和四缩合产物,再将分离后所得的二缩合和四缩合产物分别与丙酮在酸催化下缩合,得到2,2,7,7,12,12,17,17-八甲基-21,22,23,24-四氧代卟啉(反应式Ⅰ)。此法反应时间长,产物分离困难,产率也较低。我们改进了上述合成方法,利用金属离子在合成大环化合物中的模板效应(template effect),以金属镁离子作模 Oxo porphyrin is a crown ring containing furan ring, the synthesis began in 1950. Ackman once furan and acetone in the acid-catalyzed condensation to give two condensation, three condensation and four condensation products, and then after the separation of the resulting two condensation and four condensation products were acetone and acid-catalyzed condensation to give 2,2,7, 7,12,12,17,17-octamethyl-21,22,23,24-tetraoxo porphyrin (Scheme I). The reaction time is long, the product is difficult to separate and the yield is also low. We have improved the above synthesis method, utilizing the template effect of metal ions in the synthesis of macrocycles, modeling magnesium ion