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已知维生素E(VE)为血小板聚集(PA)的抑制剂。本文评价VE在血小板前列腺素(PG)代谢和二磷酸腺苷(ADP)诱导PA的作用,讨论血小板中异常的VE代谢可作为在糖尿病(DM)血管并发症有关的PA增加的机理之一。将非胰岛素依赖型DM患者分成有或无增生性视网膜病变二组,以眼底照相的结果,即多发性视网膜出血、新血管形成和出现纤维组织作为评价视网膜病变的指标。所有受检者每日服VE5mg,在研究前至少两周停用包括VE在内的抗血小板药。测定血小板聚集,ADP最终浓度为2μmol/L,血栓烷B_2(TXB_2),Siess’s法及VE含量(Thompson’s法)。
Vitamin E (VE) is known as an inhibitor of platelet aggregation (PA). This article evaluates the effect of VE on platelet prostaglandin (PG) metabolism and adenosine diphosphate (ADP) -induced PA and discusses the abnormal VE metabolism in platelets as one of the mechanisms by which PA is associated with vascular complications of diabetes mellitus (DM). Patients with non-insulin-dependent DM were divided into two groups, with or without proliferative retinopathy. The results of fundus photography, ie, multiple retinal hemorrhage, neovascularization and fibrosis, were used as indicators for evaluating retinopathy. All subjects received VE 5 mg daily, and antiplatelet drugs including VE were discontinued at least two weeks prior to the study. Platelet aggregation was measured with a final ADP concentration of 2 μmol / L, TXB_2, Siess’s method and VE content (Thompson’s method).