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目的 :观察小剂量克拉霉素、羟氨苄青霉素和洛赛克三联短疗程疗法根除幽门螺杆菌(HP)的效果。方法 :66例伴有HP阳性的慢性胃炎或十二指肠球溃疡患者 ,随机分为两组 ,第1组为7d组 ,第2组为10d组。治疗方案为克拉霉素250mg、羟氨苄青霉素1000mg、洛赛克20mg均为每日2次口服。疗程结束停药1个月后作 14C尿素呼气试验 ,阴性者为HP根除。结果 :组IHP根除率为90.6 % ,组IIHP根除率为93 %。两组间HP根除率无统计学差异 ,P>0.05。结论 :本组小剂量克拉霉素、羟氨苄青霉素和洛赛克三药联合 ,短疗程对HP的根除获得良好效果 ,副作用小 ,病人耐受性好
OBJECTIVE: To observe the effect of low-dose clarithromycin, amoxicillin and Losec short-course therapy for the eradication of Helicobacter pylori (HP). Methods: Sixty-six patients with chronic gastritis or duodenal ulcer accompanied by HP were randomly divided into two groups: group 1 was 7d and group 2 was 10d. Treatment programs for clarithromycin 250mg, amoxicillin 1000mg, Losec 20mg are 2 times a day orally. After the end of treatment for 1 month after withdrawal for 14C urea breath test, negative for HP eradication. Results: The group IHP eradication rate was 90.6%, group IIHP eradication rate was 93%. There was no significant difference in the eradication rate of HP between the two groups (P> 0.05). Conclusion: The combination of low dose clarithromycin, amoxicillin and Losec trimethoprim combined with short course of treatment has good effect on the eradication of HP with small side effects and good patient tolerance