虽然早在本世纪三十年代即发现了致敏动物肺灌流液中存在着一种能引起平滑肌收缩的物质,称为慢作用物质(Slow Reacting Substance,下简称SRS),并认为这类物质可能与哮喘等速发性过敏反应有关。但对其化学结构始终未搞清楚。直至七十年代末期Samuelsson等从不同来源的白细胞在钙通道激活剂A_(23187)的刺激下,得到了具有SRS类似生物活性的物质,采用高压液相层析、同位素掺入、气相质谱、立体化学分析等多种方法以及全合成,证明了SRS是一类花生四烯酸的衍生物,由于来源于白细胞及分子结构中含有三个共轭双键,故命名为白三烯 Although it was discovered in the thirties of the thirties that there is a substance that can cause smooth muscle contraction in sensitized animal lung perfusion fluid, called Slow Reacting Substance (SRS), and think that such substances may And asthma and other immediate allergic reaction. But its chemical structure has not been clear. Until the late seventies Samuelsson and other white blood cells from different sources in the calcium channel activator A 23187 stimulated to obtain a substance with SRS similar biological activity using high pressure liquid chromatography, isotope incorporation, gas mass spectrometry, three-dimensional Chemical analysis and other methods as well as the total synthesis, proved that SRS is a class of arachidonic acid derivatives, due to the white blood cells and molecular structure contains three conjugated double bonds, so named leukotriene