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1997年,Iovanna等在研究急性胰腺损伤的分子变化中首先克隆得到了p8基因。人的p8分子是一个由82个氨基酸组成的小分子核蛋白,分子内含有一个保守的核定位序列,蛋白质二级结构与HMG-I/Y蛋白十分相似,该分子在包括胰腺、肝脏、肾脏在内的诸多脏器受到损伤刺激后,能够在短时间内迅速、高水平地上调,因此被认为是一个应激分子(stress associated protein)。随后的研究显示该基因具有复杂的表达调节模式,在个体发育、肿瘤形成、组织损伤、心肌肥大以及糖尿病性肾病中都发挥重要作用,并且其功能表现在不同组织、细胞中不尽相同。
In 1997, Iovanna et al. First cloned the p8 gene in the study of molecular changes in acute pancreatic injury. The human p8 molecule is a small nuclear protein consisting of 82 amino acids and contains a conserved nuclear localization sequence. The secondary structure of the protein is very similar to that of the HMG-I / Y protein, which includes the pancreatic, liver and kidney After being stimulated by the damage, many organs, including organs, can rapidly and highly upregulate in a short period of time and are therefore considered to be stress associated proteins. Subsequent studies have shown that this gene has a complex expression and regulation pattern that plays an important role in individual development, tumorigenesis, tissue damage, cardiac hypertrophy and diabetic nephropathy, and its function is manifested in different tissues and cells.