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以3-氟溴苯、对溴苯腈、丙基环己基甲基氯等为原料,经过格氏反应、Suzuki反应、Witting反应、氢化反应等7步反应最终合成出化合物2,6-二氟-4-{3-氟-4’-[1-甲基-2-(4-丙基环己基)-乙基]联苯}苯基二氟甲氧基-3,4,5-三氟苯〔化合物(Ⅶ)〕,其中格氏试剂与对溴苯腈的反应中溶剂选择二甲苯;锂化反应制备硼酸中,锂化反应时间选择2 h;纯化后目标产物气相色谱纯度为99.7%(熔点82.97~85.04℃),总收率约为30%,其结构经IR、1HNMR及GC-MS确证。该化合物添加到液晶的基础配方中,能提高配方的双折射率(Δn),降低其阈值电压(Vth)。
Bromo-benzonitrile and propylcyclohexylmethyl chloride as raw materials, Grignard reaction, Suzuki reaction, Witting reaction and hydrogenation reaction were used to synthesize 2,6-difluoro-benzene -4- {3-fluoro-4 ’- [1 -methyl- 2- (4-propylcyclohexyl) -ethyl] biphenyl} phenyldifluoromethoxy-3,4,5-trifluoro Benzo [compound (VII)], wherein the solvent of the reaction between Grignard reagent and p-bromobenzonitrile is selected from xylene; and the lithiation reaction time is 2 h in the preparation of boric acid by lithiation reaction; the purity of the target product after purification is 99.7% (Melting point 82.97 ~ 85.04 ℃), the total yield of about 30%, its structure confirmed by IR, 1HNMR and GC-MS. The addition of this compound to the basic formulation of the liquid crystal increases the birefringence (Δn) of the formulation and decreases its threshold voltage (Vth).