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目的通过透射电镜技术观察Barrett食管上皮的超微结构变化,并探讨其意义。方法内镜下诊断Barrett食管,在食管下段行内镜下黏膜活检,标本分别经福尔马林、戊二醛固定,对经内镜及病理证实为Barrett食管伴肠上皮化生的黏膜行透射电镜观察。结果Barrett食管上皮超微结构显示兼有鳞状上皮和腺上皮的结构特征,并多见一种形态特征介于黏液细胞和杯状细胞之间的“中间体”细胞。结论Barrett食管上皮超微结构提示Barrett上皮可能起源于食管的多能干细胞,并具有多向分化潜能。
Objective To observe the ultrastructural changes of Barrett’s esophageal epithelium by transmission electron microscopy and to explore its significance. Methods Barrett’s esophagus was diagnosed by endoscopy. Endoscopic mucosal biopsy was performed in the lower esophagus. The specimens were fixed with formalin and glutaraldehyde, respectively. The transmucosal line of Barrett’s esophagus with intestinal metaplasia confirmed by endoscopy and pathology was transplanted Electron microscopy. Results The ultrastructure of Barrett’s esophageal epithelium showed both structural features of squamous epithelium and glandular epithelium, and more often found a morphological feature between mucinous and goblet cells. Conclusion The ultrastructure of Barrett’s esophageal epithelium suggests that Barrett’s epithelium may originate from the esophageal pluripotent stem cells and has multidirectional differentiation potential.