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目的观察17β-雌二醇(芬吗通)在人工周期冻融胚胎移植(FET)中的临床应用效果。方法选取2013年9月-2014年5月在该院施行FET的患者为研究对象,共计377个周期,将其分为自然周期组、戊酸雌二醇(补佳乐)组和芬吗通组,统计3组子宫内膜厚度、周期取消率、临床妊娠率、早期流产率和胚胎种植率的差异。结果子宫内膜正常(厚度≥8 mm)者,自然周期组周期取消率显著高于芬吗通组和补佳乐组,差异有统计学意义(P<0.05),芬吗通组与补佳乐组比较,差异无统计学意义(P>0.05);3组临床妊娠率、早期流产率和胚胎种植率比较,差异均无统计学意义(P>0.05)。子宫内膜较薄(厚度<8 mm)者,芬吗通组和补佳乐组周期取消率显著低于自然周期组,差异有统计学意义(P<0.05),芬吗通组和补佳乐组比较,差异无统计学意义(P>0.05);芬吗通组内膜厚度、临床妊娠率和胚胎种植率均显著高于自然周期组和补佳乐组(P<0.05)。结论芬吗通可成为子宫内膜较薄者FET的较好选择。
Objective To observe the clinical effect of 17β-estradiol (Fentutong) in artificial frozen-thawed embryo transfer (FET). Methods A total of 377 cycles of FET-administered patients in our hospital from September 2013 to May 2014 were selected and divided into three groups: natural cycle group, estradiol valerate (nadrogol) group, Group, statistical group 3 endometrial thickness, cycle cancellation rate, clinical pregnancy rate, early miscarriage rate and embryo implantation rate differences. Results In normal endometrium (thickness≥8 mm), the cancellation rate of spontaneous cycle group was significantly higher than that of fentanyl group and bujia tong group (P <0.05) (P> 0.05). There was no significant difference in clinical pregnancy rate, early miscarriage rate and embryo implantation rate between the three groups (P> 0.05). In the thinner endometrium (<8 mm in thickness), the cancellation rates of Fen-tong-Tong and Bu-Jia-Yue were significantly lower than those of the natural cycle (P <0.05) There was no significant difference between the music group and the control group (P> 0.05). The intima thickness, clinical pregnancy rate and embryo implantation rate were significantly higher in fentanyl group than those in natural cycle group and bujiale group (P <0.05). Conclusion Finnant may be a better choice for FET with thinner endometrium.