肿瘤细胞表面抗原的变异是研究单克隆抗体(McAb)诊断和治疗癌症的主要问题。部分肿瘤细胞表面含有的肿瘤相关抗原不足以结合足够量的McAb进行成像或治疗。近来,美国国立癌症研究所等的研究者发现体内应用α-A干扰素能增加肿瘤抗原的表达和放射性标记的McAb与小鼠移植的人结肠肿瘤的结合量。每天注射25万 Variation in tumor cell surface antigens is a major issue in the study of monoclonal antibodies (McAbs) for the diagnosis and treatment of cancer. Some tumor cells contain tumor-associated antigens that are not sufficient for imaging or treatment with a sufficient amount of McAb. Recently, researchers such as the National Cancer Institute found that the in vivo application of α-A interferon increased the expression of tumor antigens and the binding of radiolabeled McAbs to mouse colon human colon tumors. 250,000 daily injection