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目的 观察HIFU辐照兔腹主动脉粥样硬化 (atherosclerosis ,AS)血管后血流动力学的变化 ,确定HIFU的安全性。方法 以CDFI和DSA检测HIFU辐照兔AS及对照组腹主动脉后不同时间血管血流的变化 ,测定血流动力学指标。结果 48只兔 (AS组 :n1=2 4,对照组 :n2 =2 4) ,HIFU辐照后CDFI示动脉峰值血流速度、平均血流速度、阻力指数、搏动指数、血流量及血流量下降百分比均下降 (P <0 .0 5 )。DSA示动脉血流阻滞、充盈延迟 ,无血管栓塞和破裂 ;5d及 10d观察动脉血流呈向正常恢复趋势 ,对照组恢复更好。结论 HIFU辐照兔腹主动脉AS血管将导致可逆的血流动力学改变 ,HIFU辐照兔腹主动脉粥样硬化血管具有相对安全性
Objective To observe the changes of hemodynamics after HIFU irradiation in atherosclerosis (AS) blood vessels in rabbits to determine the safety of HIFU. Methods CDFI and DSA were used to detect the changes of blood flow at different time points after irradiation of HIFU in rabbits AS and control group, and the hemodynamics indexes were measured. Results 48 rabbits (AS group: n1 = 24, control group: n2 = 24) showed the peak arterial blood flow velocity, average blood flow velocity, resistance index, pulsatility index, blood flow and blood flow The percentages of decrease were all decreased (P <0.05). DSA showed arterial blood flow block, filling delay, no embolization and rupture of blood vessels. The arterial blood flow recovered to normal on 5d and 10d, and the control group recovered better. Conclusions HIFU irradiation in rabbit abdominal aorta AS blood vessels will lead to reversible hemodynamic changes, HIFU radiation rabbit abdominal aortic atherosclerotic vessels with relative safety