论文部分内容阅读
冠心病(CHD)的诊断及治疗技术在近年来有了很大进展,但对其病因学研究进展缓慢。最近大量的临床病理和流行病学研究结果显示,感染与冠心病的发生发展有关,包括细菌(幽门螺旋杆菌、流感噬血杆菌、链球菌等)、病原体(肺炎衣原体、支原体)和病毒(巨细胞病毒、单纯疱疹病毒、EB病毒、甲肝病毒、艾滋病毒、乙肝病毒等)在内的病原微生物可能是CHD发病的感染因素,感染物质可能影响粥样斑块的稳定性,细胞因子如TNF、IL-6、CRP及黏附分子等表达增强,诱发加重血管内皮损伤,加速动脉硬化的形成发展为冠心病。抗生素治疗冠心病取得一定的进展,主要是针对肺炎衣原体和幽门螺旋杆菌感染的治疗。
Diagnosis and treatment of coronary heart disease (CHD) technology in recent years has made great progress, but the etiology of slow progress. Recently a large number of clinical pathological and epidemiological studies have shown that the infection and the occurrence and development of coronary heart disease, including bacteria (Helicobacter pylori, influenza bacillus, Streptococcus, etc.), pathogens (Chlamydia pneumoniae, Mycoplasma) and the virus Such as cytomegalovirus, cytopathic virus, herpes simplex virus, Epstein-Barr virus, hepatitis A virus, HIV, hepatitis B virus, etc.) may be the causative agent of CHD. Infectious substances may affect the stability of atherosclerotic plaque. IL-6, CRP and adhesion molecules such as enhanced expression, induced vascular endothelial injury and accelerate the formation of atherosclerosis development of coronary heart disease. Antibiotic treatment of coronary heart disease made some progress, mainly for the treatment of Chlamydia pneumoniae and Helicobacter pylori infection.